It's not back until EARLY NEXT YEAR!! I might not live that long! How can they torture us? Okay, here's my best guesses for the follow-up:
1) Zak won't shoot Mike (although if I were Mike, I'd shoot the clingy and dimwitted Susan)...
2) Bree gets much, much warmer to George, the Love-crazed Pharmacist, but then finds out about his Awful Secret of the Switched Pills which killed off Rex. What kind of retribution will the human iceberg think up?
3) Newcomers Betty and Matthew Applewhite are hiding something in their new house - but what? No doubt Edie won't be able to resist some prying. Is it a gigantic four-room reflux still making moonshine? A mini-coke factory? A mutant child?
4) Lynette starts back at her old ad agency, while Tom finds 'friendship' at the 'mothers 'n' tots' club. House-father, my arse.
5) Paul somehow gets back from being dumped in the desert, to his 'son' Zak/Dana, whose real mother's been killed by the woman he thought was his mother, and who's going to find out that Mike (who's just entered the house where Zak lies in wait to kill him) is his real Dad, and not Paul...
... which brings me back to 1) and off we go!